LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures

LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures

Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer, the experimental options to investigate the specific effects of antibodies blocking inhibitory receptors are limited and it is still unclear which c...

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Bibliographic Details
Main Authors: Nicolas Gestermann, Damien Saugy, Christophe Martignier, Laure Tillé, Silvia A. Fuertes Marraco, Markus Zettl, Iñigo Tirapu, Daniel E. Speiser, Grégory Verdeil
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
checkpoint blockade
human melanoma
in vitro screening
pd-1
lag-3
autologous t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1736792

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