Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to apoptosis inducing chemotherapeutic drug temozolom...

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Bibliographic Details
Main Authors: Lanxin Luo, Jun Wang, Dawei Ding, Md Nabiul Hasan, Sung-Sen Yang, Shih-Hua Lin, Philipp Schreppel, Baoshan Sun, Yan Yin, Thomas Erker, Dandan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
bumetanide
bumetanide-derivative STS66
cell volume regulation
glioma
K+ influx
Na+-K+-Cl− cotransporter
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00911/full

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