The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recr...

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Main Authors:	Federica Fusella, Laura Seclì, Elena Busso, Anna Krepelova, Enrico Moiso, Stefania Rocca, Laura Conti, Laura Annaratone, Cristina Rubinetto, Maurizia Mello-Grand, Vijay Singh, Giovanna Chiorino, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Alessandro Morotti, Salvatore Oliviero, Isabella Castellano, Federica Cavallo, Paolo Provero, Guido Tarone, Mara Brancaccio
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01829-1

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spelling	doaj-12fe3e6cb2cb4e56ad2f805e25c156612021-05-11T07:39:25ZengNature Publishing GroupNature Communications2041-17232017-11-018111710.1038/s41467-017-01829-1The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasisFederica Fusella0Laura Seclì1Elena Busso2Anna Krepelova3Enrico Moiso4Stefania Rocca5Laura Conti6Laura Annaratone7Cristina Rubinetto8Maurizia Mello-Grand9Vijay Singh10Giovanna Chiorino11Lorenzo Silengo12Fiorella Altruda13Emilia Turco14Alessandro Morotti15Salvatore Oliviero16Isabella Castellano17Federica Cavallo18Paolo Provero19Guido Tarone20Mara Brancaccio21Department of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Life Sciences and Systems Biology, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Medical Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoCancer Genomics Laboratory, Fondazione Edo ed Elvo TempiaCancer Genomics Laboratory, Fondazione Edo ed Elvo TempiaCancer Genomics Laboratory, Fondazione Edo ed Elvo TempiaDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Clinical and Biological Sciences, University of TorinoDepartment of Life Sciences and Systems Biology, University of TorinoDepartment of Medical Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoDepartment of Molecular Biotechnology and Health Sciences, University of TorinoNF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.https://doi.org/10.1038/s41467-017-01829-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio
spellingShingle	Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis Nature Communications
author_facet	Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio
author_sort	Federica Fusella
title	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_short	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_full	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_fullStr	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_full_unstemmed	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_sort	ikk/nf-κb signaling pathway requires morgana to drive breast cancer metastasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.
url	https://doi.org/10.1038/s41467-017-01829-1
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The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

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