Research advances in tumor markers for the diagnosis of hepatocellular carcinoma

• Main Author: YANG Guimin
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2018-01-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: carcinoma; hepatocellular; tumor markers; biological; diagnosis; review
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=8705

Hepatocellular carcinoma (HCC) is a malignant tumor with a high fatality rate in the world, and alpha-fetoprotein (AFP) is the most commonly used tumor marker for HCC diagnosis. However, AFP does not have a satisfactory sensitivity or specificity and may lead to missed diagnosis when the tumor is small in the early stage of HCC. This article summarizes the clinical value of new tumor markers in the diagnosis, treatment monitoring, and prognosis judgment of HCC and analyzes the future prospects of the measurement of tumor markers for HCC. It is pointed out that combined determination of several tumor markers helps to improve the sensitivity and specificity of HCC diagnosis, and the screening and optimization of combined determination of tumor markers, noninvasive and efficient tumor markers, and individualized treatment are research hotspots in future.