Incidence and profile of C3 Glomerulopathy: A single center study

• Main Authors: M Mathur, S Sharma, D Prasad, R Garsa, A P Singh, R Kumar, P Beniwal, D Agarwal, V Malhotra
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Indian Journal of Nephrology
• Subjects: Alternate pathway; C3 glomerulopathy; membranoproliferative glomerulonephritis; plasma therapy
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=1;spage=8;epage=11;aulast=Mathur

C3 glomerulopathy has recently been described as a distinct entity. The underlying mechanism is unregulated activation of the alternate pathway of the complement system. The most common presentation is with an acute nephritic syndrome. The diagnosis is made on immunofluoroscence by the presence of isolated or dominant C3 staining. In this retrospective study, renal biopsy data were collected from 2010 to 2013 patients with C3 glomerulopathy identified and their clinical and biochemical parameters analyzed. Out of 514 biopsies available for analysis, the incidence of C3 glomerulopathy was 1.16% (n = 6). The mean age of the presentation was 26 years and the average estimated glomerular filtration rate was 30.65 ml/min/1.73 m 2 . The most common histopathological pattern was membranoproliferative glomerulonephritis (n = 4).