Piperine ameliorates SCA17 neuropathology by reducing ER stress

Piperine ameliorates SCA17 neuropathology by reducing ER stress

Abstract Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cere...

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Main Authors: Jifeng Guo, Yiting Cui, Qiong Liu, Yang Yang, Yujing Li, Ling Weng, Beisha Tang, Peng Jin, Xiao-Jiang Li, Su Yang, Shihua Li
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Neurodegeneration
Subjects:
Polyglutamine
Ataxia
Neurotrophic factor
ER stress
Online Access:http://link.springer.com/article/10.1186/s13024-018-0236-x

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