Highly efficient encapsulation of curcumin into and pH-controlled drug release from poly(ε-caprolactone) nanoparticles stabilized with a novel amphiphilic hyperbranched polyglycerol

Highly efficient encapsulation of curcumin into and pH-controlled drug release from poly(ε-caprolactone) nanoparticles stabilized with a novel amphiphilic hyperbranched polyglycerol

The hardly water-soluble curcumin with low bioavailability was successfully encapsulated into biodegradable polymeric particles by nanoprecipitation. By using the more hydrophobic poly(ε-caprolactone) (PCL) instead of poly(lactic-co-glycolic acid) 50:50 (PLGA) significantly increased drug load was a...

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Bibliographic Details
Main Authors: N. Zs. Nagy, Z. Varga, J. Mihaly, Gy. Kasza, B. Ivan, E. Kiss
Format: Article
Language:English
Published: Budapest University of Technology 2020-01-01
Series:eXPRESS Polymer Letters
Subjects:
nanomaterials
curcumin
drug carrier
polycaprolactone
hyperbranched polyglycerol
Online Access:http://www.expresspolymlett.com/letolt.php?file=EPL-0010057&mi=cd

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