Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct intera...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-20930-0 |
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doaj-12d17b4408464c90aef7ffb8954e38272021-01-31T12:20:40ZengNature Publishing GroupNature Communications2041-17232021-01-0112111110.1038/s41467-021-20930-0Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosisAvia Watson0Hao Li1Bingting Ma2Ronen Weiss3Daniele Bendayan4Lilach Abramovitz5Noam Ben-Shalom6Michael Mor7Erica Pinko8Michal Bar Oz9Zhenqi Wang10Fengjiao Du11Yu Lu12Jan Rybniker13Rony Dahan14Hairong Huang15Daniel Barkan16Ye Xiang17Babak Javid18Natalia T. Freund19Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityCentre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, Tsinghua University School of MedicineAdvanced Innovation Center for Structural Biology & Beijing Frontier Research Center for Biological Structure, Tsinghua University School of MedicineDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityPulmonary and Tuberculosis Department, Shmuel Harofe HospitalDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityPulmonary and Tuberculosis Department, Shmuel Harofe HospitalKoret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemCentre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, Tsinghua University School of MedicineBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical UniversityBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical UniversityDepartment of Internal Medicine, Division of Infectious Diseases, University of CologneDepartment of Immunology, Weizmann Institute of ScienceNational Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor InstituteKoret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemAdvanced Innovation Center for Structural Biology & Beijing Frontier Research Center for Biological Structure, Tsinghua University School of MedicineCentre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, Tsinghua University School of MedicineDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv UniversityAntibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct interaction modes in crystal structure, and mediate protection in vitro.https://doi.org/10.1038/s41467-021-20930-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund |
| spellingShingle |
Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis Nature Communications |
| author_facet |
Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund |
| author_sort |
Avia Watson |
| title |
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis |
| title_short |
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis |
| title_full |
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis |
| title_fullStr |
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis |
| title_full_unstemmed |
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis |
| title_sort |
human antibodies targeting a mycobacterium transporter protein mediate protection against tuberculosis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct interaction modes in crystal structure, and mediate protection in vitro. |
| url |
https://doi.org/10.1038/s41467-021-20930-0 |
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