Anti-Arrhythmic Potential of Coriandrum sativum Seeds in Salt Induced Arrhythmic Rats

• Main Author: Nida Rehman1, Nazish Jahan1*, Khalil-ul-Rahman2, Khalid Mahmood Khan2 and Fatiqa Zafar1
• Format: Article
• Language: English
• Published: University of Agriculture, Faisalabad 2016-11-01
• Series: Pakistan Veterinary Journal
• Subjects: Arrhythmia; Bradycardia; Coriandrum sativum; Cardiac biomarker; Electrocardiogram; Tachycardia
• Online Access: http://pvj.com.pk/pdf-files/36_4/465-471.pdf

In the present research, the anti-arrhythmic potential of Coriandrum sativum (seeds) was evaluated in BaCl2 induced tachycardia and KCl induced bradycardia in rats. Heart rate and electrocardiogram (ECG) was recorded during the experimental period. The BaCl2 increased the heart rate from 111/min to 157/min while KCL decreased the heart rate from 112/min to 60/min in the rats of positive control groups. ECG patterns also confirmed the tachy- and brady-arrhythmia in the rats of both positive control groups. The changes in biochemical cardiac biomarkers (CK-MB, LDH, AST, and ALT) were also the studied parameters. The level of cardiac biomarkers was significantly elevated in the serum of positive control rats as compared to their respective absolute controls. In case of both curative and preventive mode of treatment the elevated levels of enzymes, cardiac biomarkers were significantly reduced. Electrocardiogram (ECG) pattern revealed that the studied plant possesses a very good anti-arrhythmic potential in case of curative mode of treatment. The antiarrhythmic potential through preventive mode of treatment was also encouraging, but comparatively less than the curative mode of treatment. Anti-tachycardial potential of C. sativum was comparable with standard drug while, recovery in bradycardia was relatively slow than standard drug. Gross pathology and ECG pattern of base line group confirmed the innoxious nature of C. sativum seeds. Treatment of rats with Coriandrum sativum (100 mgkg-1 BW) normalized the heart rate and attenuated the cardiac arrhythmia.