Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

Tumour samples are heterogeneous and are comprised of multiple cell types in addition to cancer cells. Here, the authors devised a method to estimate the relative levels of haematopoietic cells in breast cancer samples and demonstrate that this correlates with prognosis.

Bibliographic Details
Main Authors: Frederick S. Varn, Erik H. Andrews, David W. Mullins, Chao Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10248
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spelling doaj-12d103b3d080434da061c3d03435a48e2021-05-11T10:35:27ZengNature Publishing GroupNature Communications2041-17232016-01-017111210.1038/ncomms10248Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profilesFrederick S. Varn0Erik H. Andrews1David W. Mullins2Chao Cheng3Department of Genetics, Geisel School of Medicine at DartmouthDepartment of Genetics, Geisel School of Medicine at DartmouthDepartment of Microbiology and Immunology, Geisel School of Medicine at DartmouthDepartment of Genetics, Geisel School of Medicine at DartmouthTumour samples are heterogeneous and are comprised of multiple cell types in addition to cancer cells. Here, the authors devised a method to estimate the relative levels of haematopoietic cells in breast cancer samples and demonstrate that this correlates with prognosis.https://doi.org/10.1038/ncomms10248
collection DOAJ
language English
format Article
sources DOAJ
author Frederick S. Varn
Erik H. Andrews
David W. Mullins
Chao Cheng
spellingShingle Frederick S. Varn
Erik H. Andrews
David W. Mullins
Chao Cheng
Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
Nature Communications
author_facet Frederick S. Varn
Erik H. Andrews
David W. Mullins
Chao Cheng
author_sort Frederick S. Varn
title Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
title_short Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
title_full Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
title_fullStr Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
title_full_unstemmed Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
title_sort integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description Tumour samples are heterogeneous and are comprised of multiple cell types in addition to cancer cells. Here, the authors devised a method to estimate the relative levels of haematopoietic cells in breast cancer samples and demonstrate that this correlates with prognosis.
url https://doi.org/10.1038/ncomms10248
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AT erikhandrews integrativeanalysisofbreastcancerrevealsprognostichaematopoieticactivityandpatientspecificimmuneresponseprofiles
AT davidwmullins integrativeanalysisofbreastcancerrevealsprognostichaematopoieticactivityandpatientspecificimmuneresponseprofiles
AT chaocheng integrativeanalysisofbreastcancerrevealsprognostichaematopoieticactivityandpatientspecificimmuneresponseprofiles
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