Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar
Abstract We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-o...
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SpringerOpen
2019-05-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | http://link.springer.com/article/10.1007/s13659-019-0209-y |
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doaj-12cd62ac3cc54554aa3c18a9b098b47f2020-11-25T02:03:35ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092019-05-019324324910.1007/s13659-019-0209-yChemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of MyanmarNay Lin Tun0Dong-Bao Hu1Meng-Yuan Xia2Dong-Dong Zhang3Jun Yang4Thaung Naing Oo5Yue-Hu Wang6Xue-Fei Yang7Southeast Asia Biodiversity Research Institute, Chinese Academy of SciencesCollege of Resources and Environment, Yuxi Normal UniversityKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesSoutheast Asia Biodiversity Research Institute, Chinese Academy of SciencesKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesForest Research InstituteKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of SciencesSoutheast Asia Biodiversity Research Institute, Chinese Academy of SciencesAbstract We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3–7), four flavonoid glycosides (8–11), and others (12–23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica. Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-019-0209-yLeea aequataVitaceaeTraditional medicinesLignansFlavonoids |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nay Lin Tun Dong-Bao Hu Meng-Yuan Xia Dong-Dong Zhang Jun Yang Thaung Naing Oo Yue-Hu Wang Xue-Fei Yang |
| spellingShingle |
Nay Lin Tun Dong-Bao Hu Meng-Yuan Xia Dong-Dong Zhang Jun Yang Thaung Naing Oo Yue-Hu Wang Xue-Fei Yang Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar Natural Products and Bioprospecting Leea aequata Vitaceae Traditional medicines Lignans Flavonoids |
| author_facet |
Nay Lin Tun Dong-Bao Hu Meng-Yuan Xia Dong-Dong Zhang Jun Yang Thaung Naing Oo Yue-Hu Wang Xue-Fei Yang |
| author_sort |
Nay Lin Tun |
| title |
Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar |
| title_short |
Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar |
| title_full |
Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar |
| title_fullStr |
Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar |
| title_full_unstemmed |
Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar |
| title_sort |
chemical constituents from ethanoic extracts of the aerial parts of leea aequata l., a traditional folk medicine of myanmar |
| publisher |
SpringerOpen |
| series |
Natural Products and Bioprospecting |
| issn |
2192-2195 2192-2209 |
| publishDate |
2019-05-01 |
| description |
Abstract We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3–7), four flavonoid glycosides (8–11), and others (12–23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica. Graphical Abstract |
| topic |
Leea aequata Vitaceae Traditional medicines Lignans Flavonoids |
| url |
http://link.springer.com/article/10.1007/s13659-019-0209-y |
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