New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.

New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.

The causes of Parkinson disease (PD) remain mysterious, although some evidence supports mitochondrial dysfunctions and α-synuclein accumulation in Lewy bodies as major events. The abnormal accumulation of α-synuclein has been associated with a deficiency in the ubiquitin-proteasome system and the au...

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Main Authors: Sonia Lehri-Boufala, Mohand-Ouidir Ouidja, Véronique Barbier-Chassefière, Emilie Hénault, Rita Raisman-Vozari, Laure Garrigue-Antar, Dulce Papy-Garcia, Christophe Morin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4305359?pdf=render

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