The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance

The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance

The growth arrest-specific transcript 5 (<i>GAS5</i>) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expressio...

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Bibliographic Details
Main Authors: George I. Lambrou, Kyriaki Hatziagapiou, Apostolos Zaravinos
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>GAS5</i>
malignancy
proliferation
invasion
metastasis
tumor growth
Online Access:https://www.mdpi.com/1422-0067/21/20/7633
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spelling doaj-12c70c75d3d64885b585902b5db4634a2020-11-25T01:53:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-01217633763310.3390/ijms21207633The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced ResistanceGeorge I. Lambrou0Kyriaki Hatziagapiou1Apostolos Zaravinos2Choremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, 11527 Goudi, Athens, GreeceChoremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, 11527 Goudi, Athens, GreeceDepartment of Basic Medical Sciences, College of Medicine, Member of QU Health, Qatar University, 2713 Doha, QatarThe growth arrest-specific transcript 5 (<i>GAS5</i>) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of <i>GAS5</i> in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that <i>GAS5</i> acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. <i>GAS5</i> seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.https://www.mdpi.com/1422-0067/21/20/7633<i>GAS5</i>malignancyproliferationinvasionmetastasistumor growth
collection DOAJ
language English
format Article
sources DOAJ
author George I. Lambrou
Kyriaki Hatziagapiou
Apostolos Zaravinos
spellingShingle George I. Lambrou
Kyriaki Hatziagapiou
Apostolos Zaravinos
The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
International Journal of Molecular Sciences
<i>GAS5</i>
malignancy
proliferation
invasion
metastasis
tumor growth
author_facet George I. Lambrou
Kyriaki Hatziagapiou
Apostolos Zaravinos
author_sort George I. Lambrou
title The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
title_short The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
title_full The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
title_fullStr The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
title_full_unstemmed The Non-Coding RNA <i>GAS5</i> and Its Role in Tumor Therapy-Induced Resistance
title_sort non-coding rna <i>gas5</i> and its role in tumor therapy-induced resistance
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-10-01
description The growth arrest-specific transcript 5 (<i>GAS5</i>) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of <i>GAS5</i> in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that <i>GAS5</i> acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. <i>GAS5</i> seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.
topic <i>GAS5</i>
malignancy
proliferation
invasion
metastasis
tumor growth
url https://www.mdpi.com/1422-0067/21/20/7633
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