The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Abstract Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are not well defined. Results By comparing publicly available liver transcriptomics data from conventiona...

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Bibliographic Details
Main Authors: Sharon Ann Barretto, Frederic Lasserre, Marine Huillet, Marion Régnier, Arnaud Polizzi, Yannick Lippi, Anne Fougerat, Elodie Person, Sandrine Bruel, Colette Bétoulières, Claire Naylies, Céline Lukowicz, Sarra Smati, Laurence Guzylack, Maïwenn Olier, Vassilia Théodorou, Laila Mselli-Lakhal, Daniel Zalko, Walter Wahli, Nicolas Loiseau, Laurence Gamet-Payrastre, Hervé Guillou, Sandrine Ellero-Simatos
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Microbiome
Subjects:
Gut microbiota
Liver
Pregnane X receptor
NR1I2
Xenobiotic metabolism
Fatty acid metabolism
Online Access:https://doi.org/10.1186/s40168-021-01050-9

Internet

https://doi.org/10.1186/s40168-021-01050-9

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