Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Pl...
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doaj-12b48b733414432e91d57f613adc033b2021-05-05T15:36:07ZengeLife Sciences Publications LtdeLife2050-084X2018-02-01710.7554/eLife.34783Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zoneElizabeth A Gould0Nicolas Busquet1Douglas Shepherd2Robert M Dietz3Paco S Herson4Fabio M Simoes de Souza5Anan Li6Nicholas M George7Diego Restrepo8https://orcid.org/0000-0002-4972-446XWendy B Macklin9https://orcid.org/0000-0002-1252-0607Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, United States; Pediatric Heart Lung Center, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, United StatesDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, United StatesCenter of Mathematics, Computation and Cognition, Federal University of ABC, BrazilJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesMyelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.https://elifesciences.org/articles/34783oligodendrocytedemyelinationolfactionsub ventricular zonemotor coordinationcognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elizabeth A Gould Nicolas Busquet Douglas Shepherd Robert M Dietz Paco S Herson Fabio M Simoes de Souza Anan Li Nicholas M George Diego Restrepo Wendy B Macklin |
spellingShingle |
Elizabeth A Gould Nicolas Busquet Douglas Shepherd Robert M Dietz Paco S Herson Fabio M Simoes de Souza Anan Li Nicholas M George Diego Restrepo Wendy B Macklin Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone eLife oligodendrocyte demyelination olfaction sub ventricular zone motor coordination cognition |
author_facet |
Elizabeth A Gould Nicolas Busquet Douglas Shepherd Robert M Dietz Paco S Herson Fabio M Simoes de Souza Anan Li Nicholas M George Diego Restrepo Wendy B Macklin |
author_sort |
Elizabeth A Gould |
title |
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_short |
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_full |
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_fullStr |
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_full_unstemmed |
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_sort |
mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2018-02-01 |
description |
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption. |
topic |
oligodendrocyte demyelination olfaction sub ventricular zone motor coordination cognition |
url |
https://elifesciences.org/articles/34783 |
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