Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Pl...

Full description

Bibliographic Details
Main Authors: Elizabeth A Gould, Nicolas Busquet, Douglas Shepherd, Robert M Dietz, Paco S Herson, Fabio M Simoes de Souza, Anan Li, Nicholas M George, Diego Restrepo, Wendy B Macklin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/34783
id doaj-12b48b733414432e91d57f613adc033b
record_format Article
spelling doaj-12b48b733414432e91d57f613adc033b2021-05-05T15:36:07ZengeLife Sciences Publications LtdeLife2050-084X2018-02-01710.7554/eLife.34783Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zoneElizabeth A Gould0Nicolas Busquet1Douglas Shepherd2Robert M Dietz3Paco S Herson4Fabio M Simoes de Souza5Anan Li6Nicholas M George7Diego Restrepo8https://orcid.org/0000-0002-4972-446XWendy B Macklin9https://orcid.org/0000-0002-1252-0607Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Neurology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, United States; Pediatric Heart Lung Center, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, United StatesDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, United StatesCenter of Mathematics, Computation and Cognition, Federal University of ABC, BrazilJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesMyelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.https://elifesciences.org/articles/34783oligodendrocytedemyelinationolfactionsub ventricular zonemotor coordinationcognition
collection DOAJ
language English
format Article
sources DOAJ
author Elizabeth A Gould
Nicolas Busquet
Douglas Shepherd
Robert M Dietz
Paco S Herson
Fabio M Simoes de Souza
Anan Li
Nicholas M George
Diego Restrepo
Wendy B Macklin
spellingShingle Elizabeth A Gould
Nicolas Busquet
Douglas Shepherd
Robert M Dietz
Paco S Herson
Fabio M Simoes de Souza
Anan Li
Nicholas M George
Diego Restrepo
Wendy B Macklin
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
eLife
oligodendrocyte
demyelination
olfaction
sub ventricular zone
motor coordination
cognition
author_facet Elizabeth A Gould
Nicolas Busquet
Douglas Shepherd
Robert M Dietz
Paco S Herson
Fabio M Simoes de Souza
Anan Li
Nicholas M George
Diego Restrepo
Wendy B Macklin
author_sort Elizabeth A Gould
title Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_short Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_full Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_fullStr Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_full_unstemmed Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_sort mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2018-02-01
description Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.
topic oligodendrocyte
demyelination
olfaction
sub ventricular zone
motor coordination
cognition
url https://elifesciences.org/articles/34783
work_keys_str_mv AT elizabethagould mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT nicolasbusquet mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT douglasshepherd mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT robertmdietz mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT pacosherson mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT fabiomsimoesdesouza mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT ananli mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT nicholasmgeorge mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT diegorestrepo mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
AT wendybmacklin mildmyelindisruptionelicitsearlyalterationinbehaviorandproliferationinthesubventricularzone
_version_ 1721459865093668864