Amyloid Precursor Proteins Are Dynamically Trafficked and Processed During Neuronal Development

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed During Neuronal Development

Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer’s Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family...

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Bibliographic Details
Main Authors: Jenna M. Ramaker, Robert S. Cargill, Tracy L Swanson, Hanil Quirindongo, Marlène Cassar, Doris Kretzschmar, Philip F. Copenhaver
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer Disease
Axonal Transport
Drosophila
Manduca
Neuromuscular Junction
neuronal migration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00130/full

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