Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain

Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.

Bibliographic Details
Main Authors: Yiheng Tu, Zening Fu, Cuiping Mao, Maryam Falahpour, Randy L. Gollub, Joel Park, Georgia Wilson, Vitaly Napadow, Jessica Gerber, Suk-Tak Chan, Robert R. Edwards, Ted J. Kaptchuk, Thomas Liu, Vince Calhoun, Bruce Rosen, Jian Kong
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17788-z
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spelling doaj-12950b10b50549f0afb08979efd453c92021-08-08T11:38:46ZengNature Publishing GroupNature Communications2041-17232020-08-0111111210.1038/s41467-020-17788-zDistinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back painYiheng Tu0Zening Fu1Cuiping Mao2Maryam Falahpour3Randy L. Gollub4Joel Park5Georgia Wilson6Vitaly Napadow7Jessica Gerber8Suk-Tak Chan9Robert R. Edwards10Ted J. Kaptchuk11Thomas Liu12Vince Calhoun13Bruce Rosen14Jian Kong15Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory UniversityDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolCenter for Functional MRI, University of California San DiegoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolBeth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Functional MRI, University of California San DiegoTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory UniversityDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolThalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.https://doi.org/10.1038/s41467-020-17788-z
collection DOAJ
language English
format Article
sources DOAJ
author Yiheng Tu
Zening Fu
Cuiping Mao
Maryam Falahpour
Randy L. Gollub
Joel Park
Georgia Wilson
Vitaly Napadow
Jessica Gerber
Suk-Tak Chan
Robert R. Edwards
Ted J. Kaptchuk
Thomas Liu
Vince Calhoun
Bruce Rosen
Jian Kong
spellingShingle Yiheng Tu
Zening Fu
Cuiping Mao
Maryam Falahpour
Randy L. Gollub
Joel Park
Georgia Wilson
Vitaly Napadow
Jessica Gerber
Suk-Tak Chan
Robert R. Edwards
Ted J. Kaptchuk
Thomas Liu
Vince Calhoun
Bruce Rosen
Jian Kong
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
Nature Communications
author_facet Yiheng Tu
Zening Fu
Cuiping Mao
Maryam Falahpour
Randy L. Gollub
Joel Park
Georgia Wilson
Vitaly Napadow
Jessica Gerber
Suk-Tak Chan
Robert R. Edwards
Ted J. Kaptchuk
Thomas Liu
Vince Calhoun
Bruce Rosen
Jian Kong
author_sort Yiheng Tu
title Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
title_short Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
title_full Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
title_fullStr Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
title_full_unstemmed Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
title_sort distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.
url https://doi.org/10.1038/s41467-020-17788-z
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