Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.
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2020-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-17788-z |
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doaj-12950b10b50549f0afb08979efd453c92021-08-08T11:38:46ZengNature Publishing GroupNature Communications2041-17232020-08-0111111210.1038/s41467-020-17788-zDistinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back painYiheng Tu0Zening Fu1Cuiping Mao2Maryam Falahpour3Randy L. Gollub4Joel Park5Georgia Wilson6Vitaly Napadow7Jessica Gerber8Suk-Tak Chan9Robert R. Edwards10Ted J. Kaptchuk11Thomas Liu12Vince Calhoun13Bruce Rosen14Jian Kong15Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory UniversityDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolCenter for Functional MRI, University of California San DiegoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolBeth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Functional MRI, University of California San DiegoTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory UniversityDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolThalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.https://doi.org/10.1038/s41467-020-17788-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiheng Tu Zening Fu Cuiping Mao Maryam Falahpour Randy L. Gollub Joel Park Georgia Wilson Vitaly Napadow Jessica Gerber Suk-Tak Chan Robert R. Edwards Ted J. Kaptchuk Thomas Liu Vince Calhoun Bruce Rosen Jian Kong |
spellingShingle |
Yiheng Tu Zening Fu Cuiping Mao Maryam Falahpour Randy L. Gollub Joel Park Georgia Wilson Vitaly Napadow Jessica Gerber Suk-Tak Chan Robert R. Edwards Ted J. Kaptchuk Thomas Liu Vince Calhoun Bruce Rosen Jian Kong Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain Nature Communications |
author_facet |
Yiheng Tu Zening Fu Cuiping Mao Maryam Falahpour Randy L. Gollub Joel Park Georgia Wilson Vitaly Napadow Jessica Gerber Suk-Tak Chan Robert R. Edwards Ted J. Kaptchuk Thomas Liu Vince Calhoun Bruce Rosen Jian Kong |
author_sort |
Yiheng Tu |
title |
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_short |
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_full |
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_fullStr |
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_full_unstemmed |
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_sort |
distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-08-01 |
description |
Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics. |
url |
https://doi.org/10.1038/s41467-020-17788-z |
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