ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, addin...

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Main Authors: M. S. Drutskaya, E. A. Gorshkova, A. S. Zhdanova, K.-S. Atretkhany, V. S. Gogoleva, R. V. Zvartsev, A. A. Kruglov, S. A. Nedospasov
Format: Article
Language:Russian
Published: SPb RAACI 2016-12-01
Series:Medicinskaâ Immunologiâ
Subjects:
interleukin-6
experimental arthritis
anti-collagen antibodies transfer
neutralizing antibodies
tnf
Online Access:https://www.mimmun.ru/mimmun/article/view/1139
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spelling doaj-12943e1321844d0c821fce0d89537cbd2021-07-29T09:02:31ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2016-12-0118656957410.15789/1563-0625-2016-6-569-574872ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIESM. S. Drutskaya0E. A. Gorshkova1A. S. Zhdanova2K.-S. Atretkhany3V. S. Gogoleva4R. V. Zvartsev5A. A. Kruglov6S. A. Nedospasov7Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian Federation Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian Federation Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian FederationEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation Lomonosov Moscow State University, Moscow, Russian Federation Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian FederationInterleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies.https://www.mimmun.ru/mimmun/article/view/1139interleukin-6experimental arthritisanti-collagen antibodies transferneutralizing antibodiestnf
collection DOAJ
language Russian
format Article
sources DOAJ
author M. S. Drutskaya
E. A. Gorshkova
A. S. Zhdanova
K.-S. Atretkhany
V. S. Gogoleva
R. V. Zvartsev
A. A. Kruglov
S. A. Nedospasov
spellingShingle M. S. Drutskaya
E. A. Gorshkova
A. S. Zhdanova
K.-S. Atretkhany
V. S. Gogoleva
R. V. Zvartsev
A. A. Kruglov
S. A. Nedospasov
ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
Medicinskaâ Immunologiâ
interleukin-6
experimental arthritis
anti-collagen antibodies transfer
neutralizing antibodies
tnf
author_facet M. S. Drutskaya
E. A. Gorshkova
A. S. Zhdanova
K.-S. Atretkhany
V. S. Gogoleva
R. V. Zvartsev
A. A. Kruglov
S. A. Nedospasov
author_sort M. S. Drutskaya
title ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_short ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_full ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_fullStr ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_full_unstemmed ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_sort role of il-6 in experimental arthritis caused by transfer of arthritogenic antibodies
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2016-12-01
description Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies.
topic interleukin-6
experimental arthritis
anti-collagen antibodies transfer
neutralizing antibodies
tnf
url https://www.mimmun.ru/mimmun/article/view/1139
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AT eagorshkova roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
AT aszhdanova roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
AT ksatretkhany roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
AT vsgogoleva roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
AT rvzvartsev roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
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AT sanedospasov roleofil6inexperimentalarthritiscausedbytransferofarthritogenicantibodies
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