Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?

Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?

Recent data suggest that intensive therapy followed by a bone marrow antotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). Twelve studies of autotransplants were analyzed to determine outcome. Results compared to data from 29 ch...

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Main Authors: Antonella Surbone, James O. Armitage, Robert Peter Gale M.D., Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 1992-09-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979200100502
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spelling doaj-128fb17ea1054959807e8af0dc8e232d2020-11-25T03:45:06ZengSAGE PublishingCell Transplantation0963-68971555-38921992-09-01110.1177/096368979200100502Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?Antonella Surbone0James O. Armitage1Robert Peter Gale M.D., Ph.D.2Department of Oncology, Sante Chiara Hospital, Pisa, ItalyDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USADepartment of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA, USARecent data suggest that intensive therapy followed by a bone marrow antotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). Twelve studies of autotransplants were analyzed to determine outcome. Results compared to data from 29 chemotherapy studies. Complete remission was reported in 53% of autotransplant recipients versus 17% of persons receiving chemotherapy. Two-year disease-free survival was 16 and 2%, respectively. It is uncertain whether these differences indicate superiority of autotransplants or reflect selection biases. Also unknown is whether similar results might not be obtained with similarly intensive treatment without an autotransplant.https://doi.org/10.1177/096368979200100502
collection DOAJ
language English
format Article
sources DOAJ
author Antonella Surbone
James O. Armitage
Robert Peter Gale M.D., Ph.D.
spellingShingle Antonella Surbone
James O. Armitage
Robert Peter Gale M.D., Ph.D.
Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
Cell Transplantation
author_facet Antonella Surbone
James O. Armitage
Robert Peter Gale M.D., Ph.D.
author_sort Antonella Surbone
title Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
title_short Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
title_full Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
title_fullStr Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
title_full_unstemmed Autotransplants in Advanced Non-Hodgkin Lymphoma: Are They Effective?
title_sort autotransplants in advanced non-hodgkin lymphoma: are they effective?
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 1992-09-01
description Recent data suggest that intensive therapy followed by a bone marrow antotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). Twelve studies of autotransplants were analyzed to determine outcome. Results compared to data from 29 chemotherapy studies. Complete remission was reported in 53% of autotransplant recipients versus 17% of persons receiving chemotherapy. Two-year disease-free survival was 16 and 2%, respectively. It is uncertain whether these differences indicate superiority of autotransplants or reflect selection biases. Also unknown is whether similar results might not be obtained with similarly intensive treatment without an autotransplant.
url https://doi.org/10.1177/096368979200100502
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AT robertpetergalemdphd autotransplantsinadvancednonhodgkinlymphomaaretheyeffective
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