Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish

SUMMARY Mutations in patatin-like phospholipase domain containing 6 (PNPLA6), also known as neuropathy target esterase (NTE) or SPG39, cause hereditary spastic paraplegia (HSP). Although studies on animal models, including mice and Drosophila, have extended our understanding of PNPLA6, its roles in...

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Bibliographic Details
Main Authors: Yang Song, Molin Wang, Fei Mao, Ming Shao, Baochang Zhao, Zhen Song, Changshun Shao, Yaoqin Gong
Format: Article
Language:English
Published: The Company of Biologists 2013-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/2/404