RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP). Here we reconstitute this process in vitro using purified transcription and replication factors. The...

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Bibliographic Details
Main Authors: Viktor Posse, Ali Al-Behadili, Jay P Uhler, Anders R Clausen, Aurelio Reyes, Massimo Zeviani, Maria Falkenberg, Claes M Gustafsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007781

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