Phase I study of celecoxib with concurrent irinotecan, cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer

Phase I study of celecoxib with concurrent irinotecan, cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer

Purpose: Preclinical findings suggest that adding targeted therapies to combination radiation-chemotherapy can enhance treatment efficacy; however, this approach may enhance normal tissue toxicity. We investigated the maximum tolerated dose, dose-limiting toxicities, and response rate when the selec...

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Bibliographic Details
Main Authors: Ritsuko eKomaki, Xiong eWei, Pamela K Allen, Zhongxing eLiao, Luka eMilas, James D Cox, Michael S O'Reilly, Joe eChang, Mary Frances McAleer, Melenda eJeter, George R Blumenschein, Merrill S Kies
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Oncology
Subjects:
Celebrex
concurrent chemoradiotherapy
CPT-11
cyclooxygenase-2 inhibitor
stage II or III non-small cell lung cancer
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00052/full

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