S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3

S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3

Background: Reduction of the Sphingosine-1-phosphate (S1P) degrading enzyme S1P lyase 1 (SGPL1) initiates colorectal cancer progression with parallel loss of colon function in mice. We aimed to investigate the effect of SGPL1 knockout on the stem cell niche in these mice. Methods: We performed immun...

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Bibliographic Details
Main Authors: Anja Schwiebs, Farha Faqar-Uz-Zaman, Martina Herrero San Juan, Heinfried H. Radeke
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
S1P lyase
colon cancer
cell cycle
quiescence
Ki-67
FOXO3
Online Access:https://www.mdpi.com/1422-0067/22/11/5682

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https://www.mdpi.com/1422-0067/22/11/5682

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