Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures

Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures

Nucleoside analogues have found widespread application as antiviral and antitumor agents, but not yet as antibacterials. Naturally occurring uridine-derived ‘nucleoside antibiotics’ target the bacterial membrane protein MraY, an enzyme involved in peptidoglycan biosynthesis and a...

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Bibliographic Details
Main Authors: Anatol P. Spork, Stefan Koppermann, Stephanie Schier (née Wohnig), Ruth Linder, Christian Ducho
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
antibiotics
natural products
nucleoside analogues
structure–activity relationships.
Online Access:https://www.mdpi.com/1420-3049/23/11/2868

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