Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A–Treated Stem Cells

Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A–Treated Stem Cells

Trichostatin A ([R-(E,E)]-7-[4-(dimethylamino) phenyl]-N-hydroxy- 4,6-dimethyl- 7-oxo-2,4-heptadienamide, TSA) affects chromatin state through its potent histone deacetylase inhibitory activity. Interfering with the removal of acetyl groups from lysine residues in histones is one of many epigenetic...

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Bibliographic Details
Main Authors: Flora Cozzolino, Ilaria Iacobucci, Vittoria Monaco, Tiziana Angrisano, Maria Monti
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
histone PTMs
limited proteolysis
mass spectrometry
TSA
activation of differentiation
Online Access:https://www.mdpi.com/1422-0067/22/4/2063

Internet

https://www.mdpi.com/1422-0067/22/4/2063

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