Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

Objective Clinical research on gene therapy has advanced the field of veterinary medicine, and gene doping, which is the illegal use of gene therapy, has become a major concern in horseracing. Since the International Federation of Horseracing Authorities defined the administration of oligonucleotide...

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Bibliographic Details
Main Authors: Teruaki Tozaki, Kaoru Karasawa, Yohei Minamijima, Hideaki Ishii, Mio Kikuchi, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Research Notes
Subjects:
Gene doping
Mass spectrometry
Therapeutic nucleotides
Thoroughbred
LC/MS/MS
Phosphorothioated oligonucleotides (PSOs)
Online Access:http://link.springer.com/article/10.1186/s13104-018-3885-5

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http://link.springer.com/article/10.1186/s13104-018-3885-5

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