Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study

Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study

Xanthine oxidase (XO) is an important target for the effective treatment of hyperuricemia-associated diseases. A series of novel 2-substituted 6-oxo-1,6-dihydropyrimidine-5-carboxylic acids (ODCs) as XO inhibitors (XOIs) with remarkable activities have been reported recently. To better understand th...

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Bibliographic Details
Main Authors: Na Zhai, Chenchen Wang, Fengshou Wu, Liwei Xiong, Xiaogang Luo, Xiulian Ju, Genyan Liu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
xanthine oxidase inhibitor
3D-QSAR
docking
pharmacophore
virtual screening
Online Access:https://www.mdpi.com/1422-0067/22/15/8122

Internet

https://www.mdpi.com/1422-0067/22/15/8122

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