Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells

Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various autoimmune diseases in model systems. We have generated mice...

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Bibliographic Details
Main Authors: Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse, Charlotte Simon, Caroline Bernhard, Dirk H. Busch, Joachim L. Schultze, Veit R. Buchholz, Susanne Stutte, Thomas Brocker
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
apoptosis
CD8 T cell priming
cross-presentation
dendritic cells
immune homeostasis
DC-maturation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00222/full

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