Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stem-specific immunity.

Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stem-specific immunity.

Long alpha helix (LAH) from influenza virus hemagglutinin (HA) stem or stalk domain is one of the most conserved influenza virus antigens. Expression of N-terminally extended LAH in E. coli leads to assembly of α-h elical homotrimer which is structurally nearly identical to the corresponding region...

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Bibliographic Details
Main Authors: I-Na Lu, Anna Kirsteina, Sophie Farinelle, Stéphanie Willieme, Kaspars Tars, Claude P Muller, Andris Kazaks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6160157?pdf=render

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