Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

Bibliographic Details
Main Authors:	Ulrich Jordis, Dirk RÃƒÂ¶seling, Petr Knesl
Format:	Article
Language:	English
Published:	MDPI AG 2006-04-01
Series:	Molecules
Subjects:	Quinazolines tyrosine kinase inhibitors.
Online Access:	http://www.mdpi.com/1420-3049/11/4/286/

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