Activated microglia induce bone marrow mesenchymal stem cells to produce glial cell-derived neurotrophic factor and protect neurons against oxygen-glucose deprivation injury

Activated microglia induce bone marrow mesenchymal stem cells to produce glial cell-derived neurotrophic factor and protect neurons against oxygen-glucose deprivation injury

In this study, we investigated interactions among microglia (MG), bone marrow mesenchymal stem cells (BMSCs) and neurons in cerebral ischemia and the potential mechanisms using an in vitro oxygen-glucose deprivation (OGD) model. Rat BMSCs were incubated with conditioned medium (CM) from in vitro cul...

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Bibliographic Details
Main Authors: Bingke Lv, Feng Li, Jie Fang, Limin Xu, Chengmei Sun, Jianbang Han, Tian Hua, Zhongfei Zhang, Zhiming Feng, Qinghua Wang, Xiaodan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Microglia
Neuron
Tumor necrosis factor
bone marrow mesenchymal stem cell
oxygen-glucose deprivation
Glial cell-derived neurotrophic factor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00283/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00283/full

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