Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis

The integrity and stability of interneurons in a cortical network are essential for proper network function. Loss of interneuron synaptic stability and precise organization can lead to disruptions in the excitation/inhibition balance, a characteristic of epilepsy. This study aimed to identify altera...

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Bibliographic Details
Main Authors: Emily Pollock, Michelle Everest, Arthur Brown, Michael O. Poulter
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001673