Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmu...

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Bibliographic Details
Main Authors: Meng-Lei Zhu, Pearl Bakhru, Bridget Conley, Jennifer S. Nelson, Meghan Free, Aaron Martin, Joshua Starmer, Elizabeth M. Wilson, Maureen A. Su
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11350
Description
Summary:Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmune encephalitis.
ISSN:2041-1723