The effect of probiotic Lactobacillus casei supplementation on the secretory immunoglobulin A level in the saliva of wistar rats
<p><strong>Introduction</strong>: Secretory immunoglobulin A (SIgA) is an antibody that plays an important role in mucosal immunity by blockading epithelial receptors inhibiting the attachment of pathogenic bacteria, especially <em>Streptococcus mutans</em> to epithelia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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DiscoverSys
2018-10-01
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| Series: | Bali Medical Journal |
| Subjects: | |
| Online Access: | https://balimedicaljournal.org/index.php/bmj/article/view/1171 |
| Summary: | <p><strong>Introduction</strong>: Secretory immunoglobulin A (SIgA) is an antibody that plays an important role in mucosal immunity by blockading epithelial receptors inhibiting the attachment of pathogenic bacteria, especially <em>Streptococcus mutans</em> to epithelial cells<em>. Lactobacillus</em> is one of the bacteria contained in probiotics, which can increase the proliferation of SIgA-producing cells. This study aims to determine the effect of probiotic <em>Lactobacillus </em><em>c</em><em>asei</em> supplementation on increasing SIgA levels in saliva of wistar rats.</p><p><strong>Methods</strong>: This study used a laboratory prospective experimental research design, with a simple randomized design in which thirty-six male wistar rats were adapted for 7 days. After adaptation, the experimental animals that fulfilled the inclusion criteria were divided into 2 groups randomly, i.e., the treatment group who received probiotic supplement <em>Lactobacillus </em><em>c</em><em>asei</em> 1.17ml / 200gBW twice daily, and the control group receiving only standard water and food, the intervention was performed for 14 days. Examination of SIgA levels in saliva was conducted with ELISA.</p><p><strong>Results</strong>: Based on Mann-Whitney analysis, the results showed significant differences in SIgA levels between treatment and control groups with median SIgA values of 26.668 ng /ml and 4,463 ng/ml, with <em>p</em> values being 0.033 (p <0.05).</p><p><strong>Conclusion</strong>: Probiotic supplementation of <em>Lactobacillus </em><em>c</em><em>asei</em> could increase SIgA levels in saliva of wistar rats.<strong></strong></p> |
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| ISSN: | 2089-1180 2302-2914 |