Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired inn...
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Elsevier
2018-09-01
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| Series: | Medical Mycology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753918300204 |
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doaj-11fef4f97cef4e9ba80fdc478b1332c12020-11-25T02:59:46ZengElsevierMedical Mycology Case Reports2211-75392018-09-012147Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patientJessica D. Workum0Suzanne W. de Jong1Mark S. Gresnigt2Katharina L. Becker3Peter Pickkers4Frank L. van de Veerdonk5Yvonne F. Heijdra6Eva Kolwijck7Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Pulmonology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Pulmonology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands; Corresponding author.Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus. Keywords: Invasive pulmonary aspergillosis, Aspergillus niger, Immune system, Intensive care unit, Oxalate crystalhttp://www.sciencedirect.com/science/article/pii/S2211753918300204 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jessica D. Workum Suzanne W. de Jong Mark S. Gresnigt Katharina L. Becker Peter Pickkers Frank L. van de Veerdonk Yvonne F. Heijdra Eva Kolwijck |
| spellingShingle |
Jessica D. Workum Suzanne W. de Jong Mark S. Gresnigt Katharina L. Becker Peter Pickkers Frank L. van de Veerdonk Yvonne F. Heijdra Eva Kolwijck Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient Medical Mycology Case Reports |
| author_facet |
Jessica D. Workum Suzanne W. de Jong Mark S. Gresnigt Katharina L. Becker Peter Pickkers Frank L. van de Veerdonk Yvonne F. Heijdra Eva Kolwijck |
| author_sort |
Jessica D. Workum |
| title |
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient |
| title_short |
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient |
| title_full |
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient |
| title_fullStr |
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient |
| title_full_unstemmed |
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient |
| title_sort |
microbiological and immunological characteristics of a lethal pulmonary aspergillus niger infection in a non-neutropenic patient |
| publisher |
Elsevier |
| series |
Medical Mycology Case Reports |
| issn |
2211-7539 |
| publishDate |
2018-09-01 |
| description |
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus. Keywords: Invasive pulmonary aspergillosis, Aspergillus niger, Immune system, Intensive care unit, Oxalate crystal |
| url |
http://www.sciencedirect.com/science/article/pii/S2211753918300204 |
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