2-Methoxy-5-{4-oxo-2-[(<em>E</em>)-2-(4-sulfamoylphenyl)ethenyl-3,4-dihydroquinazolin-3-yl]benzene-1-sulfonamide

• Main Authors: Sumi Hudiyono, Hayun, Arry Yanuar, Muhammad Hanafi
• Format: Article
• Language: English
• Published: MDPI AG 2012-07-01
• Series: Molbank
• Subjects: 4(3<em>H</em>)-quinazolinone; 2-styryl-4(3<em>H</em>)-quinazolinone; benzenesulfonamide; chlorosulfonation-amidation
• Online Access: http://www.mdpi.com/1422-8599/2012/3/M765
• ISSN: 1422-8599

The title compound, 2-methoxy-5-{4-oxo-2-[(<em>E</em>)-2-(4-sulfamoylphenyl) ethenyl-3, 4-dihydroquinazolin-3-yl] benzene-1-sulfonamide <strong>2</strong> has been synthesized by the reaction of 3-(4-methoxyphenyl)-2-styryl-4(3<em>H</em>)-quinazolinone <strong>1</strong> with an excess of chlorosulfonic acid, followed by amidation of the sulfonyl chloride product with ammonia gas. The structure of the synthesized compound was confirmed on the basis of IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and mass spectral data.