Tunable multiphase dynamics of arginine and lysine liquid condensates

Tunable multiphase dynamics of arginine and lysine liquid condensates

The design principles underlying biomolecular phase separation of membrane-less organelles remain poorly understood. Using model homopolymers, Fisher et al. show that the formation kinetics of coexisting liquid phases can be tuned by exploiting differences between arginine and lysine residues.

Bibliographic Details
Main Authors: Rachel S. Fisher, Shana Elbaum-Garfinkle
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18224-y
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spelling doaj-11f495e04dff484c867794c842249df72021-09-19T11:51:07ZengNature Publishing GroupNature Communications2041-17232020-09-0111111010.1038/s41467-020-18224-yTunable multiphase dynamics of arginine and lysine liquid condensatesRachel S. Fisher0Shana Elbaum-Garfinkle1Structural Biology Initiative, CUNY Advanced Science Research CenterStructural Biology Initiative, CUNY Advanced Science Research CenterThe design principles underlying biomolecular phase separation of membrane-less organelles remain poorly understood. Using model homopolymers, Fisher et al. show that the formation kinetics of coexisting liquid phases can be tuned by exploiting differences between arginine and lysine residues.https://doi.org/10.1038/s41467-020-18224-y
collection DOAJ
language English
format Article
sources DOAJ
author Rachel S. Fisher
Shana Elbaum-Garfinkle
spellingShingle Rachel S. Fisher
Shana Elbaum-Garfinkle
Tunable multiphase dynamics of arginine and lysine liquid condensates
Nature Communications
author_facet Rachel S. Fisher
Shana Elbaum-Garfinkle
author_sort Rachel S. Fisher
title Tunable multiphase dynamics of arginine and lysine liquid condensates
title_short Tunable multiphase dynamics of arginine and lysine liquid condensates
title_full Tunable multiphase dynamics of arginine and lysine liquid condensates
title_fullStr Tunable multiphase dynamics of arginine and lysine liquid condensates
title_full_unstemmed Tunable multiphase dynamics of arginine and lysine liquid condensates
title_sort tunable multiphase dynamics of arginine and lysine liquid condensates
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-09-01
description The design principles underlying biomolecular phase separation of membrane-less organelles remain poorly understood. Using model homopolymers, Fisher et al. show that the formation kinetics of coexisting liquid phases can be tuned by exploiting differences between arginine and lysine residues.
url https://doi.org/10.1038/s41467-020-18224-y
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