LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells

LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells

Summary: Although the functional roles of long noncoding RNAs (lncRNAs) have been increasingly identified, few lncRNAs that control the naïve state of embryonic stem cells (ESCs) are known. Here, we report a naïve-state-associated lncRNA, LincU, which is intrinsically activated by Nanog in mESCs. Li...

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Main Authors: Zeyidan Jiapaer, Guoping Li, Dan Ye, Mingliang Bai, Jianguo Li, Xudong Guo, Yanhua Du, Dingwen Su, Wenwen Jia, Wen Chen, Guiying Wang, Yangyang Yu, Fugui Zhu, Xiaoping Wan, Jiuhong Kang
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111830273X

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