Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer

Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer

Abstract Background Despite recent advances in diagnostic and therapeutic approaches for gastric cancer (GC), the survival of patients with advanced GC remains very low. Islet-1 (ISL1) is a LIM-homeodomain transcription factor, which is upregulated and promotes cell proliferation in GC. The exact me...

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Bibliographic Details
Main Authors: Qiong Shi, Xiaomei Ni, Ming Lei, Quansong Xia, Yan Dong, Qiao Zhang, Weiping Wang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Medicine
Subjects:
ISL1
Phosphorylation
CDK1
Transcription activity
Gastric cancer
Online Access:https://doi.org/10.1186/s10020-021-00302-6

Internet

https://doi.org/10.1186/s10020-021-00302-6

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