Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support

Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support

Objectives: To develop a population pharmacokinetic model of meropenem in children with sepsis receiving extracorporeal life support (ECLS) and optimize the dosage regimen based on investigating the probability of target attainment (PTA).Methods: The children with sepsis were prospectively enrolled...

Full description

Bibliographic Details
Main Authors:	Yixue Wang, Weiming Chen, Yidie Huang, Guangfei Wang, Zhiping Li, Gangfeng Yan, Chao Chen, Guoping Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Subjects:	meropenem pharmacokinetics/pharmacodynamics children sepsis even extracorporeal membrane oxygenation continuous renal replacement therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.699191/full

Similar Items

Population Pharmacokinetics of Vancomycin and Meropenem in Pediatric Extracorporeal Membrane Oxygenation Support
by: Brenda Zylbersztajn, et al.
Published: (2021-08-01)

Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis
by: Renata Černá Pařízková, et al.
Published: (2021-07-01)

Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administration of Meropenem in Patients with Severe Sepsis and Septic Shock: A Prospective Randomized Pilot Study
by: Hui-Ying Zhao, et al.
Published: (2017-01-01)

Is Meropenem as a Monotherapy Truly Incompetent for Meropenem-Nonsusceptible Bacterial Strains? A Pharmacokinetic/Pharmacodynamic Modeling With Monte Carlo Simulation
by: Xiangqing Song, et al.
Published: (2019-11-01)

An Appraisal of the Pharmacokinetic and Pharmacodynamic Properties of Meropenem-Vaborbactam
by: Eric Wenzler, et al.
Published: (2020-10-01)

Pharmacokinetics and Pharmacodynamics of Meropenem by Extended or Continuous Infusion in Low Body Weight Critically Ill Patients
by: Sonia Luque, et al.
Published: (2021-06-01)

Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis
by: Matthias Gijsen, et al.
Published: (2021-06-01)

Pharmacokinetics of meropenem in burn patients with infections caused by Gram-negative bacteria: Are we getting close to the right treatment?
by: Silvia Corcione, et al.
Published: (2020-03-01)

Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous haemodialysis: a case report
by: Jumpei Saito, et al.
Published: (2020-09-01)

Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study
by: Stephan Braune, et al.
Published: (2018-01-01)

Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial
by: Adela Benítez-Cano, et al.
Published: (2020-02-01)

Clinical Pharmacology of Meropenem in Neonates: Effects and Pharmacokinetics
by: Gian Maria Pacifici
Published: (2016-11-01)

Extended or Continuous Infusion of Carbapenems in Children with Severe Infections: A Systematic Review and Narrative Synthesis
by: Pengxiang Zhou, et al.
Published: (2021-09-01)

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor
by: Max Andresen, et al.
Published: (2018-05-01)

Population pharmacokinetics of meropenem in critically ill infant patients
by: Wanlika Yonwises, et al.
Published: (2021-10-01)

Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients
by: Milan Kaska, et al.
Published: (2018-09-01)

Synergistic Meropenem/Vaborbactam Plus Fosfomycin Treatment of KPC Producing <i>K. pneumoniae</i> Septic Thrombosis Unresponsive to Ceftazidime/Avibactam: From the Bench to the Bedside
by: Alessandra Oliva, et al.
Published: (2021-06-01)

Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria
by: Amol T. Kothekar, et al.
Published: (2020-01-01)

Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: a randomized controlled trial
by: Tospon Lertwattanachai, et al.
Published: (2020-04-01)

A pharmacodynamic strategy to optimize empirical antibiotic therapy for gram-negative bacteria in a Brazilian Intensive Care Unit
by: Carlos R.V. Kiffer, et al.

The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis
by: Ahmed A. Abulfathi, et al.
Published: (2021-06-01)

Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial
by: Philipp Simon, et al.
Published: (2020-12-01)

Meropenem pharmacokinetics during relapsing peritonitis due to ESBL‐producing Enterobacteriaciae in a liver transplant recipient
by: Kensuke Shoji, et al.
Published: (2019-11-01)

Antibacterial therapy of sepsis in extracorporeal detoxication: current problems and ways to solve them
by: A. V. Marukhov, et al.
Published: (2020-12-01)

Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
by: Mohd H. Abdul-Aziz, et al.
Published: (2017-11-01)

The potential of meropenem and piperacillin-tazobactam combination to Acinetobacter spp clinical isolates in vitro
by: Alindya Diani, et al.
Published: (2020-02-01)

Impact du sepsis et de l'épuration extra-rénale sur la pharmacocinétique des antibiotiques.
by: Penetrat-Roger, Claire
Published: (2017)

Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study
by: Weerachai Chaijamorn, et al.
Published: (2018-09-01)

Appropriate Use of Meropenem: A Pharmacy Intervention
by: Stacey Abbott, et al.
Published: (2014)

Sepsis caused by New Delhi metallo-β-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review
by: Verónica Seija, et al.
Published: (2015-01-01)

Population Pharmacokinetics of Continuous-Infusion Meropenem in Febrile Neutropenic Patients with Hematologic Malignancies: Dosing Strategies for Optimizing Empirical Treatment against Enterobacterales and <i>P. aeruginosa</i>
by: Pier Giorgio Cojutti, et al.
Published: (2020-08-01)

Modeling Approach to Optimizing Dose Regimen of Vancomycin for Chinese Pediatric Patients with Gram-Positive Bacterial Infections
by: Kai Shen, et al.
Published: (2021-04-01)

Successful cure of a patient with urosepsis using a combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review
by: Chun-Yan Zhu, et al.
Published: (2020-12-01)

Pharmacokinetic-Pharmacodynamic Correlation for Meropenem Applied to a Burn Child Using a Bioanalytical Liquid Cromatographic Method
by: Silvia R. C. J. Santos, et al.
Published: (2011-10-01)

Meropenem: A possible new culprit in eosinophilic lung diseases
by: Nathalie Abi Hatem, et al.
Published: (2017-01-01)

Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-007)
by: Joseph L. Kuti, et al.
Published: (2019-06-01)

Meropenem Induced Skin Drug Eruption in Infectious Mononucleosis: Immunological Phenomena or Non-immunological Phenomena?
by: Atousa Hakamifard, et al.
Published: (2020-01-01)

PATHOGENIC MECHANISMS OF SEPTIC NEPHROPATHY OF THE RENAL TRANSPLANTS AND THE SEARCH FOR WAYS OF SOLVING THIS PROBLEM WITH SELECTIVE USE OF MODERN EXTRACORPOREAL METHODS
by: М. Krstic, et al.
Published: (2016-02-01)

Farmacocinética do Meropenem infundido por 3 horas em pacientes criticamente enfermos em terapia renal substitutiva contínua
by: Leusin, Fabiane
Published: (2012)

Farmacocinética do Meropenem infundido por 3 horas em pacientes criticamente enfermos em terapia renal substitutiva contínua
by: Leusin, Fabiane
Published: (2012)