Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits growth of cancer cells including non-small cell lung cancer (NSCLC). Clinically, use of thiazolidinediones, which are pharmacological activators of PPARγ is associated with a lower risk of developing lung cancer. However, th...

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Bibliographic Details
Main Authors: Howard Li, Amber L Sorenson, Joanna Poczobutt, Jay Amin, Teresa Joyal, Timothy Sullivan, Joseph T Crossno, Mary C M Weiser-Evans, Raphael A Nemenoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3228753?pdf=render

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