Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines

Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines

<p>Abstract</p> <p>Background</p> <p>Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are relatively resistant to TRAI...

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Bibliographic Details
Main Authors: Wudtiwai Benjawan, Sripanidkulchai Bungorn, Kongtawelert Prachya, Banjerdpongchai Ratana
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Journal of Hematology & Oncology
Subjects:
TRAIL
methoxyflavone derivatives
apoptosis
death receptor
mitochondrial pathway
human leukemic cells
Online Access:http://www.jhoonline.org/content/4/1/52

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