Hepatic profile of domestic cats anestetized with propofol in continuos infusion rate

• Main Authors: Janh Carlo de Amorim Ferreira, Gilberto Garcia Botelho, José Luis Accetta
• Format: Article
• Language: English
• Published: Sociedade de Medicina Veterinária do Estado do Rio de Janeiro 2014-06-01
• Series: Brazilian Journal of Veterinary Medicine
• Online Access: http://rbmv.org/index.php/BJVM/article/view/507

ABSTRACT. Ferreira J.C.A., Botelho G.G. & Accetta J.L. [Hepatic profile of domestic cats anestetized with propofol in continuos infusion rate.] Perfil hepático de gatos domésticos anestesiados com propofol em infusão contínua. Revista Brasileira de Medicina Veterinária, 36(2):116-120, 2014. Cirurgia e Anatomia Topográfica, UNIPLI/Anhanguera, Rua Visconde do Rio Branco, 137, Centro, Niterói, RJ 24020-001, Brasil. E-mail: [e-mail] This study was performed to monitor the hepatic biochemical profile of cats when submitted to continuous infusion of propofol at a 0.3 mg/kg/min dosage, for 90 minutes, and comparing to results obtained from cats who received continuous infusion of saline solution. Both groups were analyzed during a pre-determined period of time totalizing 12 hours of observation and analysis. The following enzymes activity levels were determined: Aspartate-Aminotransferase (AST), Alanina-Aminotransferase (ALT), Gamma Glutamyl Transpeptidase (GGT) and Alkaline Fosfatasis (FA); serum levels of Albumin (A), Total Bilirrubin (BT) and Total Serum Proteins (PT). Twenty healthy cats were analyzed on this study, their weights varying from two to four kg and ages between three to five years old, submitted to experimental procedures performed during the months of January and February, 2010. The analysis of these results showed a major difference (p<0.05) between the ALT serum activities at the following moments: T2 (30 minutes), T3 (60 minutes), and T5 (12 hours); AST and FA serum activities at T2. None of the animals presented averages of the results above parameters of normality. The other parameters examined did not present any significant differences, concluding that total intravenous anesthesia using continuous infusion of propofol was safe to hold cats for invasive surgical procedures, therefore providing more information regarding the safe use of this drug in this species.