Astrocytes release prostaglandin E2 to modify respiratory network activity

Astrocytes release prostaglandin E2 to modify respiratory network activity

Previously (Forsberg et al., 2016), we revealed that prostaglandin E2 (PGE2), released during hypercapnic challenge, increases calcium oscillations in the chemosensitive parafacial respiratory group (pFRG/RTN). Here, we demonstrate that pFRG/RTN astrocytes are the PGE2 source. Two distinct astrocyte...

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Bibliographic Details
Main Authors: David Forsberg, Thomas Ringstedt, Eric Herlenius
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
astrocytes
brainstem
respiration
prostaglandins
neural network
chemosensitivity
Online Access:https://elifesciences.org/articles/29566

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