Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22205-0 |
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doaj-11cd2c695fc1408dbc40c83693c9f5032021-04-11T11:12:46ZengNature Publishing GroupNature Communications2041-17232021-04-0112111710.1038/s41467-021-22205-0Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activationTomohiko Matsuo0Tomoko Isosaka1Yuichiro Hayashi2Lijun Tang3Akihiro Doi4Aiko Yasuda5Mikio Hayashi6Chia-Ying Lee7Liqin Cao8Natsumaro Kutsuna9Sachihiro Matsunaga10Takeshi Matsuda11Ikuko Yao12Mitsuyoshi Setou13Dai Kanagawa14Koichiro Higasa15Masahito Ikawa16Qinghua Liu17Reiko Kobayakawa18Ko Kobayakawa19Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Cellular and Functional Biology, Institute of Biomedical Science, Kansai Medical UniversityInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, University of TokyoDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of ScienceDepartment of Optical Imaging, Institute for Medical Photonics Research, PMPERC and IMIC, Hamamatsu University School of MedicineDepartment of Optical Imaging, Institute for Medical Photonics Research, PMPERC and IMIC, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy and IMIC, Hamamatsu University School of MedicineDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Genome Analysis, Institute of Biomedical Science, Kansai Medical UniversityResearch Institute for Microbial Diseases, Osaka UniversityInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical UniversityMatsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.https://doi.org/10.1038/s41467-021-22205-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa |
| spellingShingle |
Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation Nature Communications |
| author_facet |
Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa |
| author_sort |
Tomohiko Matsuo |
| title |
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
| title_short |
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
| title_full |
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
| title_fullStr |
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
| title_full_unstemmed |
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
| title_sort |
thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory trpa1 activation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment. |
| url |
https://doi.org/10.1038/s41467-021-22205-0 |
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