Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.
Bibliographic Details
| Main Authors: |
Tomohiko Matsuo,
Tomoko Isosaka,
Yuichiro Hayashi,
Lijun Tang,
Akihiro Doi,
Aiko Yasuda,
Mikio Hayashi,
Chia-Ying Lee,
Liqin Cao,
Natsumaro Kutsuna,
Sachihiro Matsunaga,
Takeshi Matsuda,
Ikuko Yao,
Mitsuyoshi Setou,
Dai Kanagawa,
Koichiro Higasa,
Masahito Ikawa,
Qinghua Liu,
Reiko Kobayakawa,
Ko Kobayakawa |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22205-0
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