Validation studies for germ-free Smad3-/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD

Validation studies for germ-free Smad3-/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD

While the association between microbiomes and inflammatory bowel disease (IBD) is well known, establishing causal relationships between the two is difficult in humans. Germ-free (GF) mice genetically susceptible to IBD can address this question. Smad3-/- mice with defective transforming growth facto...

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Bibliographic Details
Main Authors: Jisun Paik, Stacey Meeker, Charlie C. Hsu, Audrey Seamons, Olesya Pershutkina, Jessica M. Snyder, Thea Brabb, Lillian Maggio-Price
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Gut Microbes
Subjects:
germ-free
inflammatory bowel disease
microbiome
fecal transfer
smad3
mouse model
Online Access:http://dx.doi.org/10.1080/19490976.2019.1611151

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