A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.

A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.

Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3. Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding. AstlNull mice lack the post-...

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Bibliographic Details
Main Authors: Bo Xiong, Yangu Zhao, Stephanie Beall, Anna Burkart Sadusky, Jurrien Dean
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5293279?pdf=render

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