Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest f...

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Main Authors: Nadav Elad, Szilvia Baron, Yoav Peleg, Shira Albeck, Jacob Grunwald, Gal Raviv, Zippora Shakked, Oren Zimhony, Ron Diskin
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06440-6
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spelling doaj-11b0d9221adb4b1bbbacb74016a4bfa62021-05-11T10:15:45ZengNature Publishing GroupNature Communications2041-17232018-09-01911610.1038/s41467-018-06440-6Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolutionNadav Elad0Szilvia Baron1Yoav Peleg2Shira Albeck3Jacob Grunwald4Gal Raviv5Zippora Shakked6Oren Zimhony7Ron Diskin8Department of Chemical Research Support, Weizmann Institute of ScienceDepartment of Structural Biology, Weizmann Institute of ScienceStructural Proteomics Unit, Life Sciences Core Facilities, Weizmann Institute of ScienceStructural Proteomics Unit, Life Sciences Core Facilities, Weizmann Institute of ScienceStructural Proteomics Unit, Life Sciences Core Facilities, Weizmann Institute of ScienceDepartment of Structural Biology, Weizmann Institute of ScienceDepartment of Structural Biology, Weizmann Institute of ScienceKaplan Medical Center, Rehovot, affiliated to the School of Medicine, Hebrew UniversityDepartment of Structural Biology, Weizmann Institute of ScienceThe type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest for tuberculosis drug development.https://doi.org/10.1038/s41467-018-06440-6
collection DOAJ
language English
format Article
sources DOAJ
author Nadav Elad
Szilvia Baron
Yoav Peleg
Shira Albeck
Jacob Grunwald
Gal Raviv
Zippora Shakked
Oren Zimhony
Ron Diskin
spellingShingle Nadav Elad
Szilvia Baron
Yoav Peleg
Shira Albeck
Jacob Grunwald
Gal Raviv
Zippora Shakked
Oren Zimhony
Ron Diskin
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
Nature Communications
author_facet Nadav Elad
Szilvia Baron
Yoav Peleg
Shira Albeck
Jacob Grunwald
Gal Raviv
Zippora Shakked
Oren Zimhony
Ron Diskin
author_sort Nadav Elad
title Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_short Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_full Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_fullStr Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_full_unstemmed Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_sort structure of type-i mycobacterium tuberculosis fatty acid synthase at 3.3 å resolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest for tuberculosis drug development.
url https://doi.org/10.1038/s41467-018-06440-6
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