Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway

Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway

Bibliographic Details
Main Authors: Yanli Wang, Wenping Xie, Bin Liu, Hui Huang, Wei Luo, Yu Zhang, Xiangbin Pan, Xi-Yong Yu, Zhenya Shen, Yangxin Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00520-8
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spelling doaj-119a71507f5e40198cd33e58384ff70e2021-03-21T12:20:04ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-03-01611310.1038/s41392-021-00520-8Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathwayYanli Wang0Wenping Xie1Bin Liu2Hui Huang3Wei Luo4Yu Zhang5Xiangbin Pan6Xi-Yong Yu7Zhenya Shen8Yangxin Li9Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow UniversityInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow UniversityDepartment of Cardiology, The Second Hospital of Jilin UniversityCardiovascular Department, The Eighth Affiliated Hospital, Sun Yat-sen UniversityInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow UniversityInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow UniversityDepartment of Cardiac Surgery, Fuwai HospitalKey Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, Guangzhou Medical UniversityInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow UniversityInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow Universityhttps://doi.org/10.1038/s41392-021-00520-8
collection DOAJ
language English
format Article
sources DOAJ
author Yanli Wang
Wenping Xie
Bin Liu
Hui Huang
Wei Luo
Yu Zhang
Xiangbin Pan
Xi-Yong Yu
Zhenya Shen
Yangxin Li
spellingShingle Yanli Wang
Wenping Xie
Bin Liu
Hui Huang
Wei Luo
Yu Zhang
Xiangbin Pan
Xi-Yong Yu
Zhenya Shen
Yangxin Li
Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
Signal Transduction and Targeted Therapy
author_facet Yanli Wang
Wenping Xie
Bin Liu
Hui Huang
Wei Luo
Yu Zhang
Xiangbin Pan
Xi-Yong Yu
Zhenya Shen
Yangxin Li
author_sort Yanli Wang
title Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
title_short Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
title_full Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
title_fullStr Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
title_full_unstemmed Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
title_sort stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor rb1-mediated nlrp3 inflammasome pathway
publisher Nature Publishing Group
series Signal Transduction and Targeted Therapy
issn 2059-3635
publishDate 2021-03-01
url https://doi.org/10.1038/s41392-021-00520-8
work_keys_str_mv AT yanliwang stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT wenpingxie stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT binliu stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT huihuang stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT weiluo stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT yuzhang stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT xiangbinpan stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT xiyongyu stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT zhenyashen stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
AT yangxinli stemcellderivedexosomesrepairischemicmuscleinjurybyinhibitingthetumorsuppressorrb1mediatednlrp3inflammasomepathway
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